Recombinant protein encompassing a sequence within the C-terminus region of human SRGAP2. The exact sequence is proprietary.
Alternative Synonym:
FNBP2, SRGAP3, SRGAP2A, ARHGAP34
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
