Recombinant protein encompassing a sequence within the center region of human PKR. The exact sequence is proprietary.
Alternative Synonym:
PKR, PRKR, LEUDEN, EIF2AK1, PPP1R83
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
