Recombinant protein encompassing a sequence within the C-terminus region of human SARM1. The exact sequence is proprietary.
Alternative Synonym:
SARM, HsTIR, SAMD2, hSARM1, MyD88-5
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
