TRIM25 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human TRIM25. The immunogen is located within amino acids 520 - 570 of TRIM25.
Konjugation:
Unconjugated
Alternative Synonym:
E3 ubiquitin/ISG15 ligase TRIM25,EFP,estrogen-responsive finger protein,RING finger protein 147,RING-type E3 ubiquitin transferase,RING-type E3 ubiquitin transferase TRIM25,RNF147,tripartite motif protein TRIM25,tripartite motif-containing protein 25,ubiquitin/ISG15-conjugating enzyme TRIM25,Z147,Zinc finger protein 147,zinc finger protein 147 (estrogen-responsive finger protein),zinc finger protein-147,ZNF147.
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
