LIMK1 Antibody
Artikelnummer:
ASB-OASG04247
- Bilder (3)
| Artikelname: | LIMK1 Antibody |
| Artikelnummer: | ASB-OASG04247 |
| Hersteller Artikelnummer: | OASG04247 |
| Alternativnummer: | ASB-OASG04247-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Human, Monkey, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human LIMK-1/2 around the non-phosphorylation site of T508/505. Location: 450-530aa. |
| Alternative Synonym: | LIMK, LIMK-1 |
| There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Klonalität: | Polyclonal |
| Konzentration: | 1 mg/ml |
| Molekulargewicht: | 72 kDa |
| NCBI: | 3984 |
| Formulierung: | Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
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Western Blot using COS7 |
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Western Blot using HepG2 |
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Western Blot using HepG2 |
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