CYLD Mouse Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMM86045
| Artikelname: |
CYLD Mouse Monoclonal Antibody, Unconjugated |
| Artikelnummer: |
EKL-AMM86045 |
| Hersteller Artikelnummer: |
AMM86045 |
| Alternativnummer: |
EKL-AMM86045-50UL,EKL-AMM86045-100UL |
| Hersteller: |
EnkiLife |
| Wirt: |
Mouse |
| Kategorie: |
Antikörper |
| Applikation: |
FC, WB |
| Spezies Reaktivität: |
Human, Mouse, Rat |
| Konjugation: |
Unconjugated |
| Alternative Synonym: |
Ubiquitin carboxyl-terminal hydrolase CYLD, 3.4.19.12, Deubiquitinating enzyme CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD, CYLD, CYLD1, KIAA0849 |
| Protease that specifically cleaves Lys-63-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity). |
| Klonalität: |
Monoclonal |
| Molekulargewicht: |
107.3kDa |
| NCBI: |
1540 |
| UniProt: |
Q9NQC7 |
| Puffer: |
Purified antibody in PBS with 0.05% sodium azide. |
| Reinheit: |
Affinity Purification |
| Formulierung: |
Liquid |
| Target-Kategorie: |
CYLD |
| Application Verdünnung: |
WB 1:1000-1:2000,FC 1:25-1:50 |
