Axil, Axin like protein, Axin2, Axis inhibition protein 2, Conductin
Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3beta, Dvl, and beta-catenin and promotes the GSK-3beta-mediated phosphorylation and subsequent degradation of beta-catenin .Down-regulates beta-catenin.
