Sex determining region Y box 1, sox1, SRY, SRY box containing gene 1, SRY related HMG box gene 1, Transcription factor Sox-1
Sox (Sry-related box) genes encode a family of transcription factors that play a myriad of roles in developmental processes. Sox1 and Sox2 are the earliest markers that identify neuroectodermal tissue, and these markers, together with Sox9 collectively mark neuronal stem cells (NSCs) that are present in neurogenically active areas of the mature rodent brain. Sox1 is thought to maintain the cell cycle and promote self renewal in NSCs.
