Phospho-beta Catenin (S33/S37) (7V18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05861
Produktübersicht
Artikelname:
Phospho-beta Catenin (S33/S37) (7V18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05861
Hersteller Artikelnummer:
AMRe05861
Alternativnummer:
EKL-AMRE05861-50UL, EKL-AMRE05861-100UL, EKL-AMRE05861-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
CATNB, CTNB1, CTNNB, catenin beta, beta catenin,
Produktbeschreibung
Beta-catenin is an adherens junction protein. Adherens junctions (AJs, also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed: 18077326, PubMed: 18086858, PubMed: 18957423, PubMed: 21262353, PubMed: 22155184, PubMed: 22647378, PubMed: 22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N- terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed: 17524503, PubMed: 18077326, PubMed: 18086858, PubMed: 18957423, PubMed: 21262353, PubMed: 22155184, PubMed: 22647378, PubMed: 22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed: 17524503, PubMed: 18077326, PubMed: 18086858, PubMed: 18957423, PubMed: 21262353, PubMed: 22155184, PubMed: 22647378, PubMed: 22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed: 18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed: 21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed: 18957423). Disrupts PML function and PML- NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed: 22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By simil
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
85kDa
NCBI:
1499
UniProt:
P35222
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
CTNNB1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000
