Phospho-mTOR (S2481) (4Y3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05951
Produktübersicht
Artikelname:
Phospho-mTOR (S2481) (4Y3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05951
Hersteller Artikelnummer:
AMRe05951
Alternativnummer:
EKL-AMRE05951-50UL, EKL-AMRE05951-100UL, EKL-AMRE05951-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, WB
Spezies Reaktivität:
Human, Mouse
Konjugation:
Unconjugated
Alternative Synonym:
FRAP, FRAP1, FRAP2, RAFT1, Rapamycin target protein, kinase mTOR,
Produktbeschreibung
An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed: 12150925, PubMed: 12150926, PubMed: 12231510, PubMed: 12718876, PubMed: 14651849, PubMed: 15268862, PubMed: 15467718, PubMed: 15545625, PubMed: 15718470, PubMed: 18497260, PubMed: 18762023, PubMed: 18925875, PubMed: 20516213, PubMed: 20537536, PubMed: 21659604, PubMed: 23429703, PubMed: 23429704, PubMed: 25799227, PubMed: 26018084). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed: 15268862, PubMed: 15467718, PubMed: 18925875, PubMed: 18497260, PubMed: 20516213, PubMed: 21576368, PubMed: 21659604, PubMed: 23429704). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed: 12087098, PubMed: 12150925, PubMed: 12150926, PubMed: 12231510, PubMed: 12718876, PubMed: 14651849, PubMed: 15268862, PubMed:
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
289kDa
NCBI:
2475
UniProt:
P42345
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
MTOR
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:20-1:100,IF-P 1:20-1:50
