Phospho-NAK/TBK1 (S172) (10J4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05953
Produktübersicht
Artikelname:
Phospho-NAK/TBK1 (S172) (10J4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE05953
Hersteller Artikelnummer:
AMRe05953
Alternativnummer:
EKL-AMRE05953-50UL, EKL-AMRE05953-100UL, EKL-AMRE05953-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
FTDALS4, NAK, T2K, Tbk1,
Produktbeschreibung
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed: 14703513, PubMed: 18583960, PubMed: 12702806, PubMed: 15367631, PubMed: 10581243, PubMed: 11839743, PubMed: 15485837, PubMed: 21138416, PubMed: 25636800, PubMed: 23453971, PubMed: 23453972, PubMed: 23746807, PubMed: 26611359, PubMed: 32404352). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed: 12692549, PubMed: 14703513, PubMed: 18583960, PubMed: 12702806, PubMed: 15367631, PubMed: 25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro- inflammatory and antiviral genes including IFNA and IFNB (PubMed: 12702806, PubMed: 15367631, PubMed: 25636800, PubMed: 32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed: 23453971, PubMed: 23453972, PubMed: 23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed: 25636800, PubMed: 30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMe
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
84kDa
NCBI:
29110
UniProt:
Q9UHD2
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
TBK1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000
