Phospho-ULK1 (S556) (5G1) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06045
Produktübersicht
Artikelname:
Phospho-ULK1 (S556) (5G1) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06045
Hersteller Artikelnummer:
AMRe06045
Alternativnummer:
EKL-AMRE06045-50UL, EKL-AMRE06045-100UL, EKL-AMRE06045-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse
Konjugation:
Unconjugated
Alternative Synonym:
ATG1, ATG1A, hATG1, ULK1, UNC51,
Produktbeschreibung
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed: 21460634, PubMed: 21795849, PubMed: 23524951, PubMed: 25040165, PubMed: 31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed: 18936157, PubMed: 21460634, PubMed: 21795849, PubMed: 25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed: 21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed: 21460634). May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences (PubMed: 18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed: 11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed: 25040165). Phosphorylates FLCN, promoting autophagy (PubMed: 25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed: 20921139).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
113kDa
NCBI:
8408
UniProt:
O75385
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
ULK1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:2000-1:20000
