Phospho-YAP1 (S127) (14M14) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06050
Produktübersicht
Artikelname:
Phospho-YAP1 (S127) (14M14) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06050
Hersteller Artikelnummer:
AMRe06050
Alternativnummer:
EKL-AMRE06050-50UL, EKL-AMRE06050-100UL, EKL-AMRE06050-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
65 kDa Yes associated protein, YAP, YAp 1, YAP2, YAP 65,YKI, Yorkie homolog,
Produktbeschreibung
YAP (Yes-associated protein, YAP65) was identified based on its ability to associate with the SH3 domain of Yes. Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed: 18280240, PubMed: 18579750, PubMed: 21364637, PubMed: 30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed: 18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed: 25778702). Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed: 18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage- independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed: 18579750). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed: 25849865). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
54kDa
NCBI:
10413
UniProt:
P46937
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
YAP1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,IHC 1:100-1:200
