53BP1 (2B15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06335
| Artikelname: |
53BP1 (2B15) Rabbit Monoclonal Antibody, Unconjugated |
| Artikelnummer: |
EKL-AMRE06335 |
| Hersteller Artikelnummer: |
AMRe06335 |
| Alternativnummer: |
EKL-AMRE06335-50UL, EKL-AMRE06335-100UL, EKL-AMRE06335-200UL |
| Hersteller: |
EnkiLife |
| Wirt: |
Rabbit |
| Kategorie: |
Antikörper |
| Applikation: |
ICC, IHC, WB |
| Spezies Reaktivität: |
Human |
| Konjugation: |
Unconjugated |
| Alternative Synonym: |
Tumor suppressor p53-binding protein 1, 53 BP1, p53-binding protein 1, p53BP1, TP53BP1, p53-BP1, p202, |
| May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage. Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at Lys-15 (H2AK15Ub) and histone H4 dimethylated at Lys-20 (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). |
| Klonalität: |
Monoclonal |
| Molekulargewicht: |
214kDa |
| NCBI: |
7158 |
| UniProt: |
Q12888 |
| Puffer: |
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
| Reinheit: |
Affinity purification |
| Formulierung: |
Liquid |
| Target-Kategorie: |
TP53BP1 |
| Application Verdünnung: |
WB 1:2000-1:10000,IHC 1:50-1:200,ICC/IF 1:20-1:50 |
