Alpha Synuclein (18R1) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE06801
Artikelname: Alpha Synuclein (18R1) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE06801
Hersteller Artikelnummer: AMRe06801
Alternativnummer: EKL-AMRE06801-50UL, EKL-AMRE06801-100UL, EKL-AMRE06801-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: FC, ICC, IHC, IP, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: Alpha-synuclein, NACP, non A-beta component of AD amyloid, Non-A beta component of AD amyloid, PARK1, PARK4, PD1, SNCA,
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
Klonalität: Monoclonal
Molekulargewicht: 14kDa
NCBI: 6622
UniProt: P37840
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: SNCA
Application Verdünnung: WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50



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