ANGPTL3 (1Z15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06899
Produktübersicht
Artikelname:
ANGPTL3 (1Z15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06899
Hersteller Artikelnummer:
AMRe06899
Alternativnummer:
EKL-AMRE06899-50UL, EKL-AMRE06899-100UL, EKL-AMRE06899-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
ANG5, Angiopoietin 5, Angiopoietin like 3, ANGPT5, ANGPTL3, ANL3, FHBL2,
Produktbeschreibung
Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed: 12909640, PubMed: 23661675, PubMed: 25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface, the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N- terminal domain, and is not inhibited by GPIHBP1 (PubMed: 12097324, PubMed: 19318355, PubMed: 20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids (PubMed: 17110602, PubMed: 19028676). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed: 12565906). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food, the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
54kDa
NCBI:
27329
UniProt:
Q9Y5C1
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
ANGPTL3
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000
