AP2M1 (5T7) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06975
Produktübersicht
Artikelname:
AP2M1 (5T7) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE06975
Hersteller Artikelnummer:
AMRe06975
Alternativnummer:
EKL-AMRE06975-50UL, EKL-AMRE06975-100UL, EKL-AMRE06975-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
AP-2 complex subunit mu, AP-2 mu chain, Adapter-related protein complex 2 subunit mu, Adaptin-mu2, Clathrin assembly protein complex 2 mu medium chain, Clathrin coat assembly protein AP50,
Produktbeschreibung
Adaptins are heterotetrameric subunits of adaptors, which are complexes involved in the formation of Clathrin-coated pits for vesicle-mediated endocytosis. Involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. Component of the adaptor protein complex 2 (AP-2) (PubMed:12694563, PubMed: 12952941, PubMed: 14745134, PubMed: 14985334, PubMed: 15473838, PubMed: 31104773). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed: 12694563, PubMed: 12952941, PubMed: 14745134, PubMed: 14985334, PubMed: 15473838, PubMed: 31104773). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed: 12694563, PubMed: 12952941, PubMed: 14745134, PubMed: 14985334, PubMed: 15473838, PubMed: 31104773). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed: 12694563, PubMed: 12952941, PubMed: 14745134, PubMed: 14985334, PubMed: 15473838, PubMed: 31104773). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed: 12694563, PubMed: 12952941, PubMed: 14745134, PubMed: 14985334, PubMed: 15473838, PubMed: 31104773). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed: 12694563, PubMed:<
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
50kDa
NCBI:
1173
UniProt:
Q96CW1
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
AP2M1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000
