Aurora A (8C5) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07374
Produktübersicht
Artikelname:
Aurora A (8C5) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07374
Hersteller Artikelnummer:
AMRe07374
Alternativnummer:
EKL-AMRE07374-50UL, EKL-AMRE07374-100UL, EKL-AMRE07374-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, IP, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
AIK, ARK1, AYK1, Aurora-A, Aurora-related kinase 1, BTAK, IAK1, Ipl1- and aurora-related kinase 1, STK15, STK6, Serine/threonine kinase 15
Produktbeschreibung
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed: 12390251, PubMed: 18615013, PubMed: 11039908, PubMed: 17125279, PubMed: 17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed: 26246606, PubMed: 14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed: 27335426). Required for initial activation of CDK1 at centrosomes (PubMed: 13678582, PubMed: 15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed: 18056443, PubMed: 15128871, PubMed: 14702041, PubMed: 11551964, PubMed: 15147269, PubMed: 15987997, PubMed: 17604723, PubMed: 18615013). Regulates KIF2A tubulin depolymerase activity (PubMed: 19351716). Important for microtubule formation and/or stabilization (PubMed: 18056443). Required for normal axon formation (PubMed: 19812038). Plays a role in microtubule remodeling during neurite extension (PubMed: 19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint- response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed: 14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed: 11551964). Necessary for proper cilia disassembly prior to mitosis (Pu
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
46kDa
NCBI:
6790
UniProt:
O14965
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
AURKA
Anwendungsbeschreibung
Application Verdünnung:
WB 1:2000-1:20000,IHC 1:100-1:200,IP 1:50-1:100,IF-P 1:100-1:200
