Bcl10 (9M3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07497
Produktübersicht
Artikelname:
Bcl10 (9M3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07497
Hersteller Artikelnummer:
AMRe07497
Alternativnummer:
EKL-AMRE07497-50UL, EKL-AMRE07497-100UL, EKL-AMRE07497-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
BCL10, CARMEN, CIPER, CLAP, c-E10, mE10,
Produktbeschreibung
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed: 10364242, PubMed: 10400625, PubMed: 25365219, PubMed: 24074955). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed: 24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed: 24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed: 18287044, PubMed: 27777308, PubMed: 24074955). Activated by CARD9 downstream of C-type lectin receptors, CARD9-mediated signals are essential for antifungal immunity (PubMed: 26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed: 18264101, PubMed: 18287044, PubMed: 27777308, PubMed: 24074955). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed: 10187815).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
26kDa
NCBI:
8915
UniProt:
O95999
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
BCL10
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,FC 1:200-1:1000
