Bmi1 (10S4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07586
Produktübersicht
Artikelname:
Bmi1 (10S4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07586
Hersteller Artikelnummer:
AMRe07586
Alternativnummer:
EKL-AMRE07586-50UL, EKL-AMRE07586-100UL, EKL-AMRE07586-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IHC, WB
Spezies Reaktivität:
Human, Rat
Konjugation:
Unconjugated
Alternative Synonym:
BMI1 , Polycomb complex protein BMI 1, RING finger protein 51, RNF51, PCGF4,
Produktbeschreibung
The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest. PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed: 16359901, PubMed: 26151332, PubMed: 16714294, PubMed: 21772249, PubMed: 25355358, PubMed: 27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed: 21772249, PubMed: 25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed: 15386022, PubMed: 26151332, PubMed: 21772249).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
37kDa
NCBI:
100532731
UniProt:
P35226
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
BMI1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:2000-1:10000,IHC 1:20-1:100,ICC/IF 1:20-1:100
