BMP7 (2E15) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE07601
Artikelname: BMP7 (2E15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE07601
Hersteller Artikelnummer: AMRe07601
Alternativnummer: EKL-AMRE07601-50UL, EKL-AMRE07601-100UL, EKL-AMRE07601-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: IP, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: Bmp7, Bone morphogenetic protein 7, Eptotermin alfa, OP 1, Osteogenic protein 1,
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).
Klonalität: Monoclonal
Molekulargewicht: 49kDa
NCBI: 655
UniProt: P18075
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: BMP7
Application Verdünnung: WB 1:500-1:2000,IP 1:20-1:50



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