BST2 (1O19) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07675
Produktübersicht
Artikelname:
BST2 (1O19) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07675
Hersteller Artikelnummer:
AMRe07675
Alternativnummer:
EKL-AMRE07675-50UL, EKL-AMRE07675-100UL, EKL-AMRE07675-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
Bone marrow stromal antigen 2, BST2, CD317, HM1.24 antigen, NPC A 7, Tetherin,
Produktbeschreibung
May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:22520941, PubMed: 21529378, PubMed: 20940320, PubMed: 20419159, PubMed: 20399176, PubMed: 19879838, PubMed: 19036818, PubMed: 18342597, PubMed: 18200009). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T- cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed: 22520941, PubMed: 21621240, PubMed: 21529378, PubMed: 20943977, PubMed: 20686043, PubMed: 20419159, PubMed: 20399176, PubMed: 19879838, PubMed: 19179289, PubMed: 18342597, PubMed: 18200009, PubMed: 26378163, PubMed: 31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed: 22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed: 19564354, PubMed:
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
20kDa
NCBI:
684
UniProt:
Q10589
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
BST2
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000
