CaMKII alpha (11L11) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE07883
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| Artikelname: | CaMKII alpha (11L11) Rabbit Monoclonal Antibody, Unconjugated |
| Artikelnummer: | EKL-AMRE07883 |
| Hersteller Artikelnummer: | AMRe07883 |
| Alternativnummer: | EKL-AMRE07883-50UL, EKL-AMRE07883-100UL, EKL-AMRE07883-200UL |
| Hersteller: | EnkiLife |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | FC, IP, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Konjugation: | Unconjugated |
| Alternative Synonym: | Alpha CaMKII, Camk2a, CAMKA, CaMKII, CaMKIINalpha, PK2CDD, PKCCD, |
| CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2- arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). |
| Klonalität: | Monoclonal |
| Molekulargewicht: | 54kDa |
| NCBI: | 815 |
| UniProt: | Q9UQM7 |
| Puffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Reinheit: | Affinity purification |
| Formulierung: | Liquid |
| Target-Kategorie: | CAMK2A |
| Application Verdünnung: | WB 1:2000-1:10000,FC 1:100-1:200,IP 1:20-1:50 |
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