CD33 (18N8) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE08370
Produktübersicht
Artikelname:
CD33 (18N8) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE08370
Hersteller Artikelnummer:
AMRe08370
Alternativnummer:
EKL-AMRE08370-50UL, EKL-AMRE08370-100UL, EKL-AMRE08370-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IHC, IP, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
CD33, gp67, My9, p67, SIGLEC3,
Produktbeschreibung
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed: 15597323, PubMed: 11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 28325905, PubMed: 10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP- 2 (PubMed: 10556798, PubMed: 10206955, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed: 15597323).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
40kDa
NCBI:
945
UniProt:
P20138
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
CD33
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:20-1:50,IP 1:20-1:50
