CD44 (19J7) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE08400
Artikelname: CD44 (19J7) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE08400
Hersteller Artikelnummer: AMRe08400
Alternativnummer: EKL-AMRE08400-50UL, EKL-AMRE08400-100UL, EKL-AMRE08400-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: IF, IHC, IP, WB
Spezies Reaktivität: Human, Mouse, Rat
Konjugation: Unconjugated
Alternative Synonym: LHR, CD44, CD44 antigen, CDw44, chondroitin sulfate proteoglycan 8, CSPG8, Epican, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, HSA, HUTCH1, HUTCHI, Hyaluronate receptor, MDU2, MDU3, MIC4, MUTCH1, PGP1, Phagocytic glycoprotein 1, Soluble CD44,
Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).
Klonalität: Monoclonal
Molekulargewicht: 82kDa
NCBI: 960
UniProt: P16070
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: CD44
Application Verdünnung: WB 1:500-1:2000,IHC 1:500-1:2000,IP 1:20-1:50,IF-P 1:500-1:2000



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