M6PR/IGF2R (11G10) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE13539
Artikelname: M6PR/IGF2R (11G10) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE13539
Hersteller Artikelnummer: AMRe13539
Alternativnummer: EKL-AMRE13539-50UL, EKL-AMRE13539-100UL, EKL-AMRE13539-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: FC, ICC, IHC, WB
Spezies Reaktivität: Human, Mouse, Rat
Konjugation: Unconjugated
Alternative Synonym: IGF2R, CI Man-6-P receptor, CI-MPR, M6PR, MPR 300, Insulin-like growth factor 2 receptor, M6P/IGF2R, CD222,
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).
Klonalität: Monoclonal
Molekulargewicht: 274kDa
NCBI: 3482
UniProt: P11717
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: IGF2R
Application Verdünnung: WB 1:5000-1:50000,IHC 1:200-1:500,ICC/IF 1:200-1:1000,FC 1:100-1:500



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