NGFR (18V15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE14678
Produktübersicht
Artikelname:
NGFR (18V15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE14678
Hersteller Artikelnummer:
AMRe14678
Alternativnummer:
EKL-AMRE14678-50UL, EKL-AMRE14678-100UL, EKL-AMRE14678-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, ICC, IHC, IP, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
Gp80-LNGFR, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16,
Produktbeschreibung
NGFR Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer, disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed: 26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin- dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed: 23785138).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
45kDa
NCBI:
4804
UniProt:
P08138
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
NGFR
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,IHC 1:100-1:200,ICC/IF 1:20-1:50,FC 1:50-1:100,IP 1:50-1:100
