PAX5 (2F18) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE15787
Artikelname: PAX5 (2F18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE15787
Hersteller Artikelnummer: AMRe15787
Alternativnummer: EKL-AMRE15787-50UL, EKL-AMRE15787-100UL, EKL-AMRE15787-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: FC, ICC, IHC, IP, WB
Spezies Reaktivität: Human, Mouse, Rat
Konjugation: Unconjugated
Alternative Synonym: B cell specific activator protein, B-cell lineage specific activator, BSAP, paired box 5, paired box homeotic gene 5, Paired box protein Pax-5, PAX5, transcription factor PAX 5,
AX5 May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. Interacts with DAXX. Binds DNA as a monomer. Binds TLE4. Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage- specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin- release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238).
Klonalität: Monoclonal
Molekulargewicht: 42kDa
NCBI: 5079
UniProt: Q02548
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: PAX5
Application Verdünnung: WB 1:1000-1:5000,IHC 1:1000-1:5000,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50



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