PD-L1 (CD274) (5R18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE15922
Produktübersicht
Artikelname:
PD-L1 (CD274) (5R18) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE15922
Hersteller Artikelnummer:
AMRe15922
Alternativnummer:
EKL-AMRE15922-50UL, EKL-AMRE15922-100UL, EKL-AMRE15922-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, ICC, IHC, IP, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, CD274,
Produktbeschreibung
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed: 28813417, PubMed: 28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed: 11015443, PubMed: 28813417, PubMed: 28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed: 10581077).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
33kDa
NCBI:
29126
UniProt:
Q9NZQ7
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
CD274
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:200-1:500,ICC/IF 1:100-1:200,FC 1:50-1:200,IP 1:20-1:50
