TRADD (1A3) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE19179
Artikelname: TRADD (1A3) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE19179
Hersteller Artikelnummer: AMRe19179
Alternativnummer: EKL-AMRE19179-50UL, EKL-AMRE19179-100UL, EKL-AMRE19179-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: FC, ICC, IHC, WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: AA930854, TNFR1 associated DEATH domain protein, tradd,
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153). Overexpression of TRADD leads to two major TNF- induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).
Klonalität: Monoclonal
Molekulargewicht: 34kDa
NCBI: 8717
UniProt: Q15628
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: TRADD
Application Verdünnung: WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:100,FC 1:20-1:50



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