TRAF4 (9Q19) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE19186
Produktübersicht
Artikelname:
TRAF4 (9Q19) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE19186
Hersteller Artikelnummer:
AMRe19186
Alternativnummer:
EKL-AMRE19186-50UL, EKL-AMRE19186-100UL, EKL-AMRE19186-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, WB
Spezies Reaktivität:
Human, Mouse
Konjugation:
Unconjugated
Alternative Synonym:
MLN 62, RING finger protein 83, TRAF4, CART1, MLN62, RNF83
Produktbeschreibung
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystinerich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkappaB. Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed: 31076633, PubMed: 32268273, PubMed: 33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed: 30352854). Ubiquitinates SMURF2 through Lys-48-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed: 31076633). Promotes Lys-63-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed: 32357935). In addition, promotes an atypical Lys-29-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed: 33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed: 32268273).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
54kDa
NCBI:
9618
UniProt:
Q9BUZ4
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
TRAF4
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,FC 1:10-1:100
