TRAF6 (6S7) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE19188
Produktübersicht
Artikelname:
TRAF6 (6S7) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE19188
Hersteller Artikelnummer:
AMRe19188
Alternativnummer:
EKL-AMRE19188-50UL, EKL-AMRE19188-100UL, EKL-AMRE19188-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, Interleukin-1 signal transducer, RING finger protein 85, TRAF6, RNF85, TRAF 6, TRAF-6,
Produktbeschreibung
TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses. Members of the TRAF family share a common carboxy-terminal TRAF domain which mediates interactions with associated proteins, many also contain amino-terminal Zinc/RING finger motifs. E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed: 18347055, PubMed: 19713527, PubMed: 19465916). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed: 19675569). Leads to the activation of NF-kappa-B and JUN (PubMed: 16378096, PubMed: 17135271). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed: 18093978, PubMed: 18758450). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed: 8837778, PubMed: 19825828, PubMed: 12140561). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF- kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
60kDa
NCBI:
7189
UniProt:
Q9Y4K3
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
TRAF6
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,FC 1:50-1:100
