TRIB3 (4E15) Rabbit Monoclonal Antibody, Unconjugated

Artikelnummer: EKL-AMRE19262
Artikelname: TRIB3 (4E15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer: EKL-AMRE19262
Hersteller Artikelnummer: AMRe19262
Alternativnummer: EKL-AMRE19262-50UL, EKL-AMRE19262-100UL, EKL-AMRE19262-200UL
Hersteller: EnkiLife
Wirt: Rabbit
Kategorie: Antikörper
Applikation: WB
Spezies Reaktivität: Human
Konjugation: Unconjugated
Alternative Synonym: C20orf97, NIPK, SINK, SKIP3, TRB3, Trib3, Tribbles homolog 3, Tribbles pseudokinase 3, Tribbles3,
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the Thr-308 phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15781252, PubMed:15775988). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the Thr-308 phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230).
Klonalität: Monoclonal
Molekulargewicht: 40kDa
NCBI: 57761
UniProt: Q96RU7
Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit: Affinity purification
Formulierung: Liquid
Target-Kategorie: TRIB3
Application Verdünnung: WB 1:1000-1:5000



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