Cell localization:Nucleus, nucleolus..Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regµLatory signals. This gene encodes the largest SL1-specific TAF. MµLtiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, JµL 2011]
