GCLC,GLCL,GLCLC,Glutamate--cysteine ligase catalytic subunit,GCS heavy chain,Gamma-ECS,Gamma-glutamylcysteine synthetase
Cell localization:Cytoplasm.Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regµLatory subunit. This locus encodes the catalytic subunit, while the regµLatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010],
