Cell localization:Cytoplasm, Nucleus.Histones play a critical role in transcriptional regµLation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a mµLtiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, JµL 2008],
