BBC3,PUMA,Bcl-2-binding component 3,JFY-1,p53 up-regmuLated modmuLator of apoptosis
Cell localization:Mitochondrion.This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, Dec 2011],
