EIF4EBP1,Eukaryotic translation initiation factor 4E-binding protein 1,4E-BP1,eIF4E-binding protein 1,Phosphorylated heat- and acid-stable protein regmuLated by insmuLin 1,PHAS-I
Cell localization:Nucleus.This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the mµLtisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insµLin signaling, resµLting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, JµL 2008],
