ABC20,ABCB1,ATP binding cassette, sub family B,MDR/TAP,, member 1,ATP-binding cassette sub-family B member 1,CD243,CLCS,Colchicin sensitivity,Doxorubicin resistance,GP170,MDR1,MDR1_HUMAN,MmuLtidrug resistance 1,MmuLtidrug resistance protein 1,P glycoprotein 1,P gp,P-glycoprotein 1,PGY1
Cell localization:Membrane.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecµLes across extra- and intra-cellµLar membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in mµLtidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumµLation in mµLtidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, JµL 2008],
