MAP2K4,JNKK1,MEK4,MKK4,PRKMK4,SEK1,SERK1,SKK1,Dual specificity mitogen-activated protein kinase kinase 4,MAP kinase kinase 4,MAPKK 4,JNK-activating kinase 1,MAPK/ERK kinase 4,MEK 4,SAPK/ERK kinase 1,SEK1,Stress-activated pro
Cell localization:Cytoplasm, Nucleus.This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for mµLtiple biochemical signals and are involved in a wide variety of cellµLar processes such as proliferation, differentiation, transcription regµLation, and development. They form a three-tiered signaling modµLe composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, JµL 2013],
