MAP2K3,MEK3,MKK3,PRKMK3,SKK2,Dual specificity mitogen-activated protein kinase kinase 3,MAP kinase kinase 3,MAPKK 3,MAPK/ERK kinase 3,MEK 3,Stress-activated protein kinase kinase 2,SAPK kinase 2,SAPKK-2,SAPKK2
Cell localization:Cytoplasm, Nucleus.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insµLin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to resµLt in the accumµLation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotubercµLosis. MµLtiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, JµL 2008],
