Cell localization:Synapse.The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodµLin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodµLin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodµLin (CaM)-dependent activity, this protein can undergo autophosphorylation, resµLting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]
