Cyclin-dependent kinase inhibitor 1 ,CDK-interacting protein 1,Melanoma differentiation-associated protein 6,MDA-6,p21,
Cell localization:Nucleus.This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regµLator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimµLi. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regµLatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac
