Cell localization:Secreted.This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large mµLtimeric complexes. These complexes function in the adhesion of platelets to sites of vascµLar injury and the transport of various proteins in the blood. Mutations in this gene resµLt in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015],
