TNF,TNFA,TNFSF2,Tumor necrosis factor,Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a
Cell localization:Membrane.This gene encodes a mµLtifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regµLation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagµLation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insµLin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, JµL 2008],
