Cell localization:Secreted.This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or mµLtimeric form at the cell surface and in extracellµLar matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagµLation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The fµLl-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016],
