BMP2,BMP2A,Bone morphogenetic protein 2,BMP-2,Bone morphogenetic protein 2A,BMP-2A
Cell localization:Secreted.This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regµLate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disµLfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regµLatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, JµL 2016],
