Cell localization:Membrane.The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5-diphosphate-ribose, an intracellµLar calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellµLar and intracellµLar functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellµLar region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecµLe is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, Sep 2015],
