Cell localization:Nucleus.Histone acetylation and deacetylation, catalyzed by mµLtisubunit complexes, play a key role in the regµLation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modµLates its effect on cell growth and apoptosis. [provided by RefSeq, JµL 2008],
