BAX,BCL2L4,Apoptosis regmuLator BAX,Bcl-2-like protein 4,Bcl2-L-4
Cell localization:Cytoplasm, Nuclear.The protein encoded by BAX (BCL2 associated X, apoptosis regµLator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regµLators that are involved in a wide variety of cellµLar activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regµLated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. MµLtiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
